Comments on: Is the Course of Disease for Rheumatoid Arthritis Becoming Milder?

By: Kelly Young

Kelly Young — Sat, 17 Apr 2010 20:01:30 +0000

It has been 5 days and I’ve not yet commented on this blog. I’m catching up on replies today. This post was the first in a week of blogs on a theme, ending with Friday’s post: Would Relying on Patient Generated Data Make a Difference? which highlights the work of Dr. Ethan Basch about the discrepencies between patient’s testimony about their symptoms and clinicians’ interpretation of that data. Dr. Basch has found that the clinicians’ determination of symptoms is “less” than that of patients in every way he studied it.

I found the study in this post a few months ago because I found it cited several times. I went to read the original because I thought it was worth a look since it has been relied on heavily by other writers.

As you may guess by my subsequent posts, I stand by this one. I did not state nor imply that the study was invalid or that it’s conclusions are wrong. Ironically, I am occasionally accused of being too much of an advocate for the assumption that Biologics tend to lessen the severity of RA disease or slow damage. Sometimes, I’m portrayed as the poster child for that view.

What I do here in a blog is report facts and raise questions that I find relevant as a patient. Unlike other bloggers whom I’ve seen, I do not delete comments which challenge my statements.

Instead, I attempt to continue the conversation with more blogs and further research and more questions that I hope will lead to more answers and help for those with RA.

There is much more I could say about the specific topics of the post. There is a post that I’ve long planned about the first question I raised here & the 2nd one was covered by the Dr. Basch post. There are still many unanswered questions about RA & the ways that it is measured. It would be beyond the scope of this post to examine and explicate every aspect of that. I did not claim to have done that. I cannot see where I have denigrated either a country or its scientists. Scientists ask questions & patients should too.

By: Alicia Hoover

Alicia Hoover — Thu, 15 Apr 2010 13:10:37 +0000

I suppose that we are all allowed the freedom to express our emotions here thanks to Kelly… even annoyance! I personally think that it’ hard for us to think of things being “milder” when we experience such painful symptoms on a daily basis. especially when for some of us over time these symptoms get worse not “milder” even with meds. So Thanks Kelly for allowing us a forum to express our not so “mild” emotions regardless of what studies say we are supposed to be feeling or experiencing! I suppose it is all a matter of perspective, hmmm?

By: Chelsea

Chelsea — Wed, 14 Apr 2010 06:06:13 +0000

By: Chelsea

Chelsea — Wed, 14 Apr 2010 05:12:33 +0000

See this paper done by a US and a Swiss researcher in 2006. I'm sure there are probably some more recent ones to find. Several studies have suggested that severity of rheumatoid arthritis has decreased over the past decades. In particular, progression of radiographic joint damage seems to have declined over time, but it is not clear whether the disease itself has become milder or whether antirheumatic treatments have become more effective. This study attempted to analyse the direct causal effect of time of diagnosis on disease progression, to examine the hypothesis of a secular trend towards a milder disease. The crude analysis of both radiographic joint damage and functional disability confirms a significant trend towards milder disease in recent decades. However, after controlling for differences in antirheumatic treatment regimens, the trend for milder disease over time disappears, both for radiographic joint damage and for functional disability. This suggests that the observed trend towards milder disease in rheumatoid arthritis is largely attributable to more effective antirheumatic treatment and not to a secular trend towards milder disease.

By: Chelsea

Chelsea — Wed, 14 Apr 2010 02:00:54 +0000

I have to mainly agree with Dad with RA that a huge amount of research has come out of the Netherlands on RA – more than I’ve ever seen out of the US. And Thar, I’ve probably seen a US article or two stating the same conclusion, that on the whole/big picture, it is getting milder in that they are not seeing as many severly disabled in wheelchairs, nor are they seeing as many cases with serious EXTRA-articular manifestations such as severe vasculitis, heart or lung disease. I take it to mean that the newer meds starting with MTX and later ARE S-L-O-W-I-N-G the joint damage down, and perhaps preventing those nastier extra-articular manifestations in many cases. I agree with everyone else that it’s STILL NOT ENOUGH as we are still side-lined in our daily lives from pain and fatigue that makes us give up our social lives and living life to its fullest, even if many of us are still able to just-barely scrape enough energy together to work still. Given that we are still side-lined to a considerable degree, it’s hard to remember to remind ourselves to be greatful that it’s not worse – but that doesn’t invalidate how badly we still feel. And we are all, patients, doctors, and outsiders alike, still prone to jumping to conclusions without stopping to take the time to consider everything. It’s human nature. At least we do have sites like this where we can vent our frustrations that are still real AND significant.

By: Jamie

Jamie — Wed, 14 Apr 2010 01:25:18 +0000

I wish my RA was “milder” than it was before. I value the personal opinions of all the responders on your site Kelly. Each one of us on here are the owners of a nasty disease that knows no boundaries. I feel it is disrespectful to come onto this site or any other site and tell anyone how they should feel or respond to the content herein. Each one of us in the USA and many other countries have the right to voice our own opinion. My opinion may not rub every single person the right way, but I have a right to state it. It is the responsibility of others to tolerate my opinion even though they may not agree with it. Bashing someone else opinions or telling someone how they should feel about an article is plain poor judgment and lacking in maturity. I am grateful for your blog with its wealth of information and insight Kelly. I only wish that ALL responders to your blog could be tolerate of you and everyone else.

By: Dadwithra

Dadwithra — Tue, 13 Apr 2010 06:06:21 +0000

“Milder” seems to be the word that’s stirring up emotions. It may have been chosen for lack of a better word. There is a reason that the year 1985 is mentioned several times in this paper. Pre 1985 statistically more patients ended up in wheelchairs or were bedridden. Since this date early RA has been treated increasingly more aggressive in the Netherlands, with the result that less patients are severely crippled by the disease. Obviously these patients are still limited in every aspect of their lives, but compared to pre 1985 the onset of the disease is “milder”.

We must not forget this is a scientifically based paper published in a renowned medical journal. It deals with fact and scientific data. How we experience and live with RA is very hard to quantify, which is why papers like these only deal with aspects of this disease that can be statistically analyzed. So it’s obvious that patients who read this paper will not like part of the content.

I find myself quite annoyed by some of the comments here and some of the things said by Kelly. The Netherlands leads the world in arthritis research, a lot of great work has been and is being done to fight this disease. In fact the mission statement of Dutch Arthritis Foundation that funds a lot of this research is quite bold: “Rid the world of this dreaded disease.” We are all benefitting from this research. This paper is an extract and is written in a certain medical, historical and socio economical context of a country you do not understand. Which puts the last paragraph in a different perspective, but that not seem to stop some of you to jump to certain erroneous conclusions.

The people who wrote this paper and papers like these work tirelessly to fight arthritis, to help us alleviate our suffering. They deserver to be treated with respect and they deserve our gratitude.

By: Jamie via facebook

Jamie via facebook — Tue, 13 Apr 2010 02:54:18 +0000

I WISH, HOPE, PRAY, CROSS EVERYTHING…, that milder were the case but….I’m not convinced! I’m not sure what to make of anything yet since most of the new meds have no real history behind them. Both the old and the new meds MAY (IF lucky) help with the RA but can lead to some serious issues, especially when you have docs that just want to write … See Moreeverything off! (bios are helping me for now but MTX just taken away so?) This disease NEEDS clinical research BUT the treatment needs to be one of Compassion, Trust, Understanding,… for the people dealing with this ugliness! BELIEVE me, I WOULD NOT wish this disease on ANYONE (and I don’t have it nearly as bad as some at this point)! BUT there are days (esp. when I read what people are dealing with) I wish every rheumy could experience it…in ALL degrees…in ALL its variants, just so they had some sort of connection between what people REALLY go through and what the ‘studies’ say. You can play games with numbers to tell whatever story you want – see it all the time! I don’t understand why there isn’t the trust in the patient. They like to ‘simply’ link inflammation as the key indicator for activity and pain – which my exp. tells me differnetly! When the Rheumys see these studies it seems this is what gets reported back to people so some are not getting the RELIEF they need and DESERVE! Ask me you are asking the questions they should have been asking all along…

By: Becky

Becky — Tue, 13 Apr 2010 02:36:33 +0000

I know personally I can totally understand how this is possible. When I look at the treatment back when I was first diagnosed in 1992, there wasn’t much hope and certainty of disability because of systemic degradation. Now, there are drugs that help minimize that degradation so there is a potential for less damage, not that it happens for everyone. For me, I can’t reverse the damage that has been done but the bios are helping to keep any additional damage from occurring or keeps the damage that does occur to a dull roar so to speak. That being said, I don’t, however, believe that the disease itself is becoming milder. We are just treating it better (realizing not everyone is in this category though). It definitely would be interesting if someone here in the U.S. would do a study on this…..However it probably isn’t economical or high-profile enough for someone to waste their time on. Yeh, I know….Bitter much??? lol.

By: Wren

Wren — Mon, 12 Apr 2010 16:02:48 +0000

Based on that last paragraph, the conclusions of the rest of the study appear questionable. As you and Terry both said, the drugs used today often do mask the symptoms of RA to some degree in some people, though certainly not all. That study seems useless to me, unless it was done solely to help the pharmacological companies look good. I certainly don’t consider it conclusive or accurate. What a waste of time.