News about Rheumatoid Arthritis Treatment Options

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Cost-effectiveness and Rheumatoid Arthritis treatment options

An April 28, 2010 editorial in Arthritis Research and Therapy discusses a study published in March. Scott and Kingsley write, “Doubts about the relative benefits of TNF inhibitors have surfaced in early RA.” This study and other recent data have caused them to doubt the relative “cost-effectiveness” of Biologic therapy as a treatment option in early RA. They illuminate the new study called The loss of health status in rheumatoid arthritis and the effect of biologic therapy: a longitudinal observational study as saying that “cost effectiveness of TNF inhibitors may be overestimated.” They say that alternative treatment options with Biologics ought to be explored which might be more effective and more cost-effective. “For example, short courses of Biologics during flares may be as effective as long term use.”

“New data from Wolfe and Michaud question the widespread use of TNF inhibitors in established RA… (They) conclude that TNF inhibitors may provide only modest incremental benefits over best conventional therapy as currently used in North America. If they are correct, the economic argument underpinning the widespread use of TNF inhibitors in established RA is unsustainable.”

 Do researchers Wolfe and Michaud want to change options for Rheumatoid Arthritis treatment with regard to Biologics? I’m not sure. We can each read it and see for ourselves. Here’s one quote from their conclusion: “The estimated incremental 10-year total direct medical cost for this benefit (Biologic therapy) was $159,140. Biologic therapy retards RA progression, but its effect is far less in the community than is seen in clinical trials. Consequently, cost-effectiveness is substantially less than that estimated from clinical trial data.”

A flare-specific Rheumatoid Arthritis treatment option?

At one point, I thought I had gotten the message “early and aggressive” treatment, including the possibility of Biologic therapy, is the best of all Rheumatoid Arthritis treatment options. Great to know, I thought. All we have to do is get the word out to every patient. Then, I realized many doctors were still using the old pyramid approach to treating Rheumatoid Arthritis. Great to know the score, I thought. All we have to do is teach the doctors. Then, I read this: “widespread use is unsustainable.” Where are we now? All we have to do is convince the researchers? Hopefully not.

What’s so wrong with only treating Rheumatoid Arthritis aggressively during flares? How about providing us an objective measure of a Rheumatoid Arthritis flare, for one thing? In the last few weeks, several patients have told me stories with a version of this scenario: External joint swelling and inflammation markers were reduced, while symptoms of joint pain, weakness, and stiffness continued. The rheumatology doctors told these patients that a modified diagnosis or reduced treatment plan may be in order. In each case, the stunned patient planned to find a new doctor.

Speaking of Rheumatoid Arthritis treatment options…

Tomorrow is my regular four-month check up with the rheumatology specialist. Here I am trying to finish up the blog early enough to get myself well rested so I will look bright and presentable at the appointment. It’s conventional wisdom that professionals treat folks better who look respectable, so I always put my best foot forward – as crooked as it may be. Maybe I shouldn’t try so hard not to look sick.

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Kelly Young. All rights reserved.

This entry was posted on Thursday, April 29th, 2010 at 7:05 am and is filed under RA Research, Resources, and Rheumatology. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.


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