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20 Responses to “Rheumatoid Arthritis CRP Levels”

    1. Thanks for explaining what this CRP blood test is for. Sounds like it could give a false hope regarding inflammation. My levels have been under control but I think I have more bone erosion and loss than active inflamation.

    2. Jane says:

      Hmmm. During a recent flare that I considered bad my crp was 6 and my esr was 45. I am also seronegative. It’s frustrating to me! I feel horrid but my dr has no indicators. Makes me wonder!

    3. Telyn says:

      My crp was only elevated at first. Now it’s normal but my ESR still gets to 80 or more.

    4. Debbie says:

      While I have very active RA, my CRP and sed rate have never been elevated. I am seropositive. Fortunately, my rheumy has been very aggressive with my treatment despite my normal CRP and sed rates. Still looking for an effective treatment…

    5. Telyn says:

      My ESR tracks correctly but my new insurance requires I get labs at a lab mill, and it will always be normal due to the delay in them running the tests. So my rheumatologist rarely checks them anymore. I’ll only get an accurate reading in the ER or urgent care.

    6. Actually in my case, I was on biologics but had to go off when we were trying to get pregnant with our second baby. During those 2.5 years I went off the biologic and I think that’s when the damage was done. We gave up on baby #2 cause pain was getting too bad, so I went back on Remicade and got pregnant after the first Infusion (then my RA doc tells me it can help with fertility). So the Remicade is controlling the pain now but those years that I had joint damage, I can’t quite get back. But I now have 3 beautiful baby boys.

    7. Bob says:

      I had no elevated CRP levels when diagnosed with Psoriatic Arthritis 1987 but it was obvious with raw flesh and Rumatoid pain though it took 6 months to find someone who could diagnose it. Many years and different treatments later I was at a point where to continue getting the bioglogic mess I needed to have a certain number to qualify. I had just finished a flare but somehow the numbers came up. Many more years later it is of little interest to specialists what works or hurts or even show much interest in looking at you as it all just the numbers. I have definitely declined in the last 12 months in all areas of health but ‘whinging’ is looked down on and as long as you are reasonable, I am an optimist by nature, there is no interest in examination physically or by questioning.

    8. Marti says:

      I’m seropositive for RD but have never had an elevated CRP or ESR as well as little swelling in my joints. I did well on Remicade but had to stop because of developing autoimmune hepatitis. For the last 8 months my dr has been confused as to why I have pain. She finally sent me to get an ultrasound and her office called to let me know that my RD was fairly active and I’m beginning to get bone errosions so she would like to add another medication. I’m glad the ultrasound could show what I’m feeling.

    9. Marla Nolan says:

      I always (almost) have negative labs CRP and ESR. But, the new Vectra DA shows severe RA. I have bad joint damaged hands, feet and back so after 28 years there is no question whether or not I have RA. It’s obvious. But, I remember years of docs not believing. It’s too bad for the patient!

    10. Rena says:

      Is there a range docs tend to go by for CRP? I only ask because I am still pending a diagnosis and my most recent blood work came back with CRP 90.1. September it was 10.5, October it was 14.1 and this past one there was a huge jump.

      • Dear Rena,
        The reference ranges are different for each lab for good reason (different ways to estimate) so you must look at the range listed in your results. If it wasn’t given to you, ask for that.
        Regardless of any standard I’ve seen, 90 is very high.
        CRP is not definitive for RD but something is obviously going on with those changes as you said. Good luck.

    11. Rena says:

      Thank you, The reference range was 0.0-4.9. My Sed Rate was slightly high at 38(this is the first time ESR has been high). The only thing is I was being treated for Pneumonia at the time of my most recent labs. I have no idea if that would impact it or not. Hoping for answers soon for sure. I have been on plaqunil and Relafin and those are my levels on those. Nothing seems to work :/

    12. Julie Rodriguez says:

      I have normal CRP just diagnosed 2/2017 w/RA –
      Every thing normal except SED & 2 messed up joints L hand w/excruciating pain in R hand & wrist
      After labs & exam RA doc said i will treat as RA
      I had sonogram it confirmed erosions
      I was like WOW already
      I am seronegative RA. It all started with L hand-trigger finger.

      • Thanks for sharing Julie. There’s proof even “seronegative” can be aggressive. For anyone reading who had doubts.
        I’m glad you found a good doc who knows the value of ultrasound.

    13. Claire says:

      Hello all,
      I was diagnosed with inflammatory arthritis (RF positive) 14 years ago! (However never fulfilled criteria for Rheumatoid arthritis!). I am currently on Methotrexate and Sulfasalazine. All CRP and ESR levels have always been considered normal.I always hope my Rheumatology team understand when I tell them I have had many flare ups and can feel when most of my body is in pain and stiffness. I do wish they would do ultrasounds instead of relying so heavily on blood markers to show inflammation. Despite all I can see for myself that certain joints have changed. Anyway thankyou for these posts. They highlight what many of us with “normal” blood markers probably feel!

    14. JESSICA CAMP says:

      I’ve read a lot about ESD, RF, and CCP. I was only recently diagnosed about a month ago. My doctor sent some of blood off to a lab in California that apparently does a very extensive autoimmune pannel. When I went for my follow up/DX appt last month she went over all the labs, both that one and the local ones and the xray.
      First local, my CRP was 10.4 and ESD 18. She said that showed there was inflamation.
      More extensive – Tier 1 negative.
      Tier 2 – postive ANA 20 units
      SLE-Associated ANA (same as above) 20 units positive. HEp-2 cell fluoresence 1:320 speckled nucleur pattern. She said all this showed that I didn’t have Lupus but there was certainly some autoimmune issues. So my Rheumatoid auto-antibodies. All were low but one which I dont hear a lot about and I’m curious about what people’s opinions are.
      My Anti-MCV was 69 U/mL. She said this was more sensitive and everything together showed her early stages RA.
      (Also, x-rays of hands, feet and hips showed no damage as of yet.)
      Is the Anti-MCV something most consider accurate or is it even looked at.
      Also, how often do you have blood rest ran to check these numbers? Can they fluctuate during flares and remission? I have so many queations and I’m work on a list when I go back in 3 weeks for another follow-up but I would like to be read up with support to back up my questioning. I have pretty bad edema pretty much everyday in my feet and legs and some pain in my chest/mostly back betweem my shoulder blades. Should i push to have test done on my heart? I have one eye that waters non-stop and lately they have both been getting a grainy, heavy, tired feeling. It last about 10 mins and goes away? I don’t want to be “that”patient and I feel like such a hypochondriac lately. I took two doses of methotrexate, then the morning after the second dose woke up with a flaming UTI. No warning. I have been on an antibiotic for that since the 19th. Two doses left and now I’m having pain in the area of my kidney on my left side and it occasional feels like its shooting down the my bladder. Had to miss last Fridays Methotrexate dose and was in horrible pain all weekend (thats how I found this blog I’ve been obsessed with since, looking for relief from the pain). Called the doctor Monday and they called me in a methylprednisolone pack. Started it yeatersay before breakfast. Had racing, pounding heart last night. Today a very flushed face, chest and legs, and lightheadness accompanied it. Nurse said not to take it until they can talk to the doctor. Hoping to hear back tomorrow.
      Is this normal? Is this what I should expect? Or is this just medication trual and error? Should I ask for a referral to see a urologist?
      I’m sorry. I didn’t mean to get into all that. I was mostly curious about the test. :)

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