Rheumatoid Arthritis Treatments

List of disease-modifying anti-rheumatic drugs (DMARDs) used for Rheumatoid Arthritis
List of biologics used for treatment of Rheumatoid Arthritis
List of less-commonly used DMARDs for Rheumatoid Arthritis

Common Rheumatoid Arthritis Medications

   

Disease-modifying anti-rheumatic drugs (DMARDs) used for RA
US Brand name Manufacturer Generic name Administration method Dose schedule Mode of action
Arava Sanofi-Aventis leflunomide oral daily inhibits a specific mitochondrial enzyme
Azulfidine Pfizer sulfasalazine oral twice a day immune suppression through IL-1 & TNFα
Imuran Prometheus Labs azathioprine oral daily immune suppression through inhibiting cell proliferation
Plaquenil Sanofi-Aventis hydroxychloroquine oral daily inhibits stimulation of toll-like receptor
Rheumatrex Stada / various methotrexate oral or sub-cutaneous or intramuscular injection weekly inhibits enzymes for purine metabolism & possibly interferes with T-cells
Xeljanz Pfizer tofacitinib citrate oral twice a day immune suppresion by inhibiting Janus kinase

Biologic DMARDs used for Rheumatoid Arthritis

   

9 Biologics used for treatment of Rheumatoid Arthritis
US Brand name Manufacturer Generic name Administration method Dose schedule Mode of action
Actemra Genentech / Roche tocilizumab IV infusion monthly inhibits IL-6
Cimzia UCB (Union Chimique Belge) certolizumab pegol sub-cutaneous injection every 2 weeks inhibits TNFa
Enbrel Amgen (via Pfizer) etanercept every 2 weeks weekly inhibits TNFa
Humira Abbvie adalimumab sub-cutaneous injection every 2 weeks inhibits TNFa
Kineret Sobi anakinra sub-cutaneous injection daily inhibits IL-1
Orencia Bristol-Myers Squibb abatacept IV infusion or sub-cutaneous injection weekly injection or monthly IV after loading dose inhibits T-cells
Remicade Janssen (via Johnson & Johnson) infliximab IV infusion every 8 weeks after loading doses inhibits TNFa
Rituxan Genentech / Roche rituximab IV infusion 6 months (4 to 12 months depending on disease activity) reduces B-cells
Simponi Centocor (via Johnson & Johnson) golimumab sub-cutaneous injection monthly inhibits TNFa

DMARDs less commonly used for Rheumatoid Arthritis

More rarely used DMARDs which may be used with severe systemic Rheumatoid disease when other treatments fail.

Immune suppressing drugs used as DMARDs
US Brand name Manufacturer Generic name Administration method Dose schedule Mode of action
Cuprimine / Depen Valeant / Meda penicillamine daily oral reduces T-lymphocytes & inhibits macrophage function & decreases IL-1
Cytoxan Bristol-Myers Squibb cyclophosphamide intravenous every 2 weeks immune suppresion
Ridaura Prometheus Labs auranofin (gold salts) oral 1-3 times daily anti-mitochrondrial activity & induced cell apoptosis
Sandimmune & Neoral Novartis cyclosporine oral twice a day reduces T-cell function
Solganal Schering aurothioglucose /intramuscular gold (parenteral gold) injection weekly anti-mitochrondrial activity & induced cell apoptosis
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