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3 Responses to “Safe Acetaminophen Dosage with Chronic Pain”

    1. Jim Logajan says:

      I would like to suggest that anyone taking acetaminophen or methotrexate consider also taking Resveratrol because the latter has shown to protect the liver in studies on rodents. A search of Google (or Google Scholar) for the keywords “reserveratrol acetaminophen” yields links to article abstracts such as:

      http://www.sciencedirect.com/science/article/pii/S1386634606000477
      http://www.sciencedirect.com/science/article/pii/S0378427415001617
      http://www.sciencedirect.com/science/article/pii/S0278691515001234
      http://onlinelibrary.wiley.com/doi/10.1002/jat.1249/full

      Keywords “reserveratrol methotrexate” yielded, among others, these papers:

      https://ejournals.library.ualberta.ca/index.php/JPPS/article/view/7920
      http://journals.sagepub.com/doi/abs/10.1177/0960327112468178
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565222/

      It seems resveratrol is generally protective of the liver, as indicated by this study which fed rats a liver toxin, carbon tetrachloride, and found it helped protect the rat livers:

      http://onlinelibrary.wiley.com/doi/10.1002/jat.1249/full

    2. Catherine says:

      It’s funny because I prefer Ibropuen and find it works better except for Excedrin migraine which really helps my headaches. I am very careful and tend to only take pain meds when absolutely necessary which basically means I’m always in pain.

    3. Marla Nolan says:

      Kelly, its safer to limit to 2g or 2000mg.. I have taken MTX for 28 years and the only increase in liver enzymes I’ve had was when I took 4000mg. Went off and the came back down. Now I limit and no problems.

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