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I keep reading about various treatments, but what if you have had an allergic reaction to MTX & Humira. Now i can’t take either of these – Have there been any studies done using something else entirely?
One thing that didn’t seem to be measured or compared was the amount of time suffering until a treatment began to work. bDMARDS can work rapidly- but triple therapy can take awhile. In the extra months it can take triple therapy to work, a patient can not only be in severe unremitting pain, but lose their job and put strain on family and finances.
So even if, at the end of 6 months or a year, the treatments are equal; how can the horrible pain and suffering until that time be ignored? How can this not be measured? This trial really made me angry- to think of the pain endured and the lives forever changed- because somehow suffering for several months is ok if the end result is the same? I don’t think so!
I’d also like to add that 24 weeks can seem like a heck of a long time. They should be measuring this at 2 and 4 and 6 weeks…. I believe that TT would not hold a candle to bDMARDS. A better trial would be to get the RA under control ASAP with bDMARDS and only then to initiate a double randomized placebo trial with TT & bDMARDS. Then if the RA stays controlled either way it would make sense. Of course it takes actual understanding of the suffering involved to realize that an extra 20 weeks of severe pain is not humane.
I tried triple therapy before I went on to biologics. I really hoped that the lower cost, lower tech medications alone would be effective for me. Unfortunately, they weren’t. Now I’m on my 4th biologic in conjunction w/methotrexate and plaquenil. It’s great that triple therapy works for some, though.
The HAQ looks comparable but to me the Sharp score,erosions and joint space narrowing look worse. Do you think so?
The main reason I wanted to take biologics was the sense of well being but a close second was the better effect on bones. That was the info I found 6 years ago. I felt really unhappy to find out that damage could progress on methotrexate.
My husband thinks your picture is the shadow of a branch. To me it looks like two little bird feet sticking up