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I am excited about this. This is really good news for patients to have an oral med as strong as the injections and infusions.
I was filled with RA despair with having failed DMARDS ALL 3 ANTI TNF BIOLOGICS AND my last try with Remicade infusions doing nothing. Add my morning pity crying before I try to get out of bed and lo and behold I read your post in the new XELJANZ (Zeljanz)
My CYTOKINE TNF AND IL 6 factors are both high. My SED IS NORMAL NOW SO I KNOW THERE IS MUCH MORE GOING ON in my body.
Remicade was supposed to lower both and did not
With this new oral pill supposedly attacking THE HUB OF THE INFLAMMATION MADE ME EXCITED to call my RA doctor first thing this morning to get a ‘script when available.
Thank you RA WARRIOR for your website brought sunlight to my day! EXCUSE iPhone brevity I am away from my computer.
I was on Remicade for 5 years and it was wonderful until it stopped working. I have had reactions to Orencia, Rituxan (that was an ER visit) and now they want to try Actemra. My doctor is the head of Rheumatology at a major University medical center and is on the fence with this drug and has yet to prescribe it until there is more data. I would love to hear if anyone has taken it and how it’s effected their RA and any side effects. Cost is a huge factor for me since I’m disabled on Medicare and I don’t qualify for the rebate programs and my husband and I make too much for any financial aid. More information from other patients would be very helpful. Thanks!
There is an even newer JAK inhibitor and it only supresses 1 of the 3 JAK’s. It is being made and just completed Phase 2 trials in Belgium. See GLPG0634.
Gosh I hope these new drugs (hopefully specifically) for Rheumatoid come to Australia soon.
We have tried everything new that has become approved over the last fifteen-20 years. It works for about 6-12 months then fizzles out. Xeljanz for about 4 months so far has allowed the daily prendisone intake to go from 40 to 30 over about 2 months. We are going to keep trying to reduce but it does not seem probable yet. Goal is 20 per day. A little more pain meds are in order but the tradeoff seems favorable. My case is very severe but I’ve had it for 30 years(I’m 65) We’re hopeful again!
Good luck Bob. I hope it works for you. Thirty years is a long time.
Why aren’t doctors checking RA patients TNF and IL6 factors, – have had RA 25 tears now.
Do not just check SED Etc. certain biologics are made to decrease cytokines but few vicims have these blood tests done. An example is MY TNF WAS NORMAL BUT MY INTERLEUKIN 6 was off the charts. My experienced RA doctor told me there were no tests. There are. I found them at Quest and it was found that Xeljanz dramatically dropped my il6.
It was 54 prior to taking Xeljanz and normal range 3 – post Xeljanz!
Others could be in the same boat. My god. I am so angry I’ve had – to for decades – be my own physician but in this course of having to wait my joints have been severely damaged. I am on my 5th month and my blood tests are all normal with this drug
other bios help with TNF factors but some of us have a different problem. My TNF was normal. That’s why Humira helped for such a short time. SINCE XELJANZ is supposed to stop the inflammatory cytokines action at the hub, as it suggests, others should get a pre and post full cytokines blood panel done. PFIZER has 2 co pay programs because the drug is so expensive. If someone wants to email me I can give you tel numbers on where to begin Medicare does not pay either.
You may think you are not eligible but you might be surprised because Pfizer wants this drug to be successful and obviously it is too expensive for the majority.
There are 4 cytokines but INTERLEUKIN 6 and TUMOR NECROSIS FACTOR are the two common ones that RA drug studies are based upon