Unusual Methotrexate Side Effects
Many patients take low enough doses of methotrexate that they don’t even have side effects…
But, some strange methotrexate side effects are for real
No one ever told me methotrexate could have side effects. I’m not complaining! I think that worked for me. I didn’t approach the treatment with fear.
Don’t get me wrong – there was drama. But it was based on other things: Wean your baby. Swallow these pills for the rest of your life. Hope it helps you walk. Give up occasional beer and wine…
Without any fears of methotrexate side effects, I didn’t set myself up for failure. I didn’t have to worry about whether the side effects were partially psychosomatic or not. I was more likely to talk myself out of side effects than into them. And more likely to give the treatment a chance to work.
What are some weird methotrexate side effects?
This is not about the common side effects like nausea and minor hair loss. There are some more odd side effects of methotrexate that have either been described to me or I’ve encountered myself. I have not had all these myself, but the ones that I did have were not until my dose reached the maximum amount for my body mass.
- Metallic taste
- Breast tenderness
- Menstrual changes
- Mood changes
- Lower GI cramping
- Brain fog
- Rashes or blisters
Some methotrexate weird side effects probably aren’t
I don’t think that I’ve ever seen an Oxford Journal abstract titled Weird Methotrexate Side Effects, have you? But patients talk about it. There are plenty of places online where you can find some pretty extreme lists of side effects. Some are more realistic than others.
It can be difficult to isolate which medicine is responsible for which side effect. Often prednisone is to blame. But don’t rule out the Rheumatoid Arthritis itself. Going off of treatment when RA is flaring can make it obvious many problems are actually caused by the RA.
Recommended reading:
- Methotrexate and Rheumatoid Arthritis: Is Alcohol Consumption Safe?
- More common Methotrexate Side Effects
- 7 pages of straight talk on mtx: Methotrexate and Rheumatoid Arthritis
Subscribe to feed
Don’t know if MTX caused my RA-ILD (aka RA Lung), but it SURE didn’t help. If I was voting, I’d say the MTX had a huge hand in it. Like prednisone, it helps the symtoms, but the long tern effects make me wonder now….was it worth it.
Dakota – I hate to be a Debbie-Downer, but I suspect MTX played a big role in my new diagnosis, Intersticial lung disease (aka RA Lung). My Rheumy wouldn’t “commit”, however, she immediately took me completely off the MTX when she diagnosed me. I’ve done a lot of reading and research, and I’m am pretty sure the MTX had a hand in it. I was on it for nearly 11 years. Like prednisone, its a double edged sword. It surely helped with the RA symptoms, but had I known then, what I know now, I might have refused it.
I didn’t find out till 3 weeks ago that you shouldn’t consume grapefruit or grapefruit juice for 24 hours before and after taking methotrexate.
Almost 8 years since my diagnosis and now I find it out.
I am suppose to methotrexate, however I feel horrible all the time, like I have the flu, so I stopped taking it, I do the Humia shots only, now but they just let me have enough movement that I know I have a lot of pain and lots of swelling, I now an taking prednisone, but need to take 5 – 15 mg a day to get any relieve, what is worst the methotrexate or prednisone for my long term health?
I’ve been taking MTX for a bit over two years. Most of my RA symptoms were in my hands. My doctor put me on hydroxychloroquin and wanted to start MTX, but I said no. When my second index finger mimicked the first and would not straighten out, I agreed to try the MTX. After 6 or 8 months my doctor said I was in remission. During the time when my fingers were crackling and not bending properly, he had me go to OT, and that was really helpful. I’ve been aware of this site for a long while, but have stayed away until now. My side effects to MTX certainly haven’t gotten better (I was on the largest dose–10 pills). I take a lot of folic acid and still have queasiness. I take a ginger capsule with each meal on my MTX day, along with a capsule of DGL licorice. It seems to help, but lately the nausea is still there. I asked my doc a couple of weeks ago if I could taper the MTX, and he said yes! but slowly. So now I’m down to 8 tabs. I will certainly try the green olives mentioned elsewhere on the site. MTX is definitely the drug I love to hate and hate to love.
Been on Methorexate 20 mg / week for 6 months plus. Definitely increased joint pain for 24-48 hours after taking it, then this disappears. But worst of all is the horrendous fatigue, which lasts 48-72 hours after taking it. Literally bed-ridden, then energy picks up (although not to normal levels) the last 3 days before having to dose again… This drug is a real struggle. It has helped my joint pain overall, but at what cost….?
Anyone experience extreme bloating and stomach ache with MTX. I just finished my 4th week with MTX, since then I looked like 4months pregnant.
First dose MTX and bed ridden for 11 hours with severe pain. Glad seen this site to know not alone. Thanks for the other info