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Fascinating and very, very informative! I have no doubt he has found a key if not many keys here to use…now we just need to figure out how to use these keys to resolve this disease. We are fortunate to have him on our team!
I am reading these installments and wondering. It seems that we who struggle with this disease hold answers to only half of the question. We are genetically disposed to it – TRUE. But something happened to us that triggered the onset. It is fascinating for me to ponder what that was. I was not in the midst of some major stressful time that I can recall and I had not been ill. (Most likely many odd triggers exist.) But WHAT keeps these myriad triggers from starting up RA in others who are genetically disposed? I think that a wealth of information must exist in our female, 40+ family members who are well and have not yet had any reason to discover any propensity for RA lurking in their genes. I think that would be fascinating research. Find these “lucky” folks and let’s learn from them! Are none of them “type A” personalities who stress out about stuff? Are they super-health nuts who rarely eat fast food? What might they have in common to have dodged this bullet? Some other gene perhaps? Hmmmm. I just keep wondering who might embark on such a research journey? And where would they get the money to do it?
Suzy,
Some of the complexity behind the questions you pose I intend to address in two upcoming posts. These additional details may help you better understand the nature of the problem. By and large, however, the up-front answer to your hypothetical questions is that environmental determinants for RA, like many late-onset chronic diseases, remain a big black box. If I had to guess, I would say that the possibilities you raised are not among the major factors involved. But that’s just a guess.
23andMe v3 does provide data for:
rs6822844
rs660895
rs13192841
rs10499194
rs6920220
My watch list also contains:
rs2837960
rs6910071
rs2395175
rs3817964
Great series of articles that you have done here!
Thanks for that! Nice to see readers actually contributing real data to this discussion. I’m a firm believer in crowdsourcing improved healthcare.