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Concerning the Gene responsible for RA being linked to Diabetes type 1, I have RA and my son has diabetes type 1.
I hear that all the time Sue. Either parent child or RA patient with both symptoms. It’s definitely a clue. I hope your son is doing ok.
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Kelly, this is an interesting read and something i kind of already knew..i had been by told by my consultant that if you get one auto immune response you are more than likely to get another.. (this was later confirmed by my sister who is a doctor – and had been doing some research at the time) ..as you may already know i have Coeliac disease and RA – both quite difficult but manageable at the moment…trouble is sometimes i don’t know whether its because i’ve had gluten slipped into my food, or my meds for RA that have upset my tummy at times!! all very confusing..
This is a great post and very informative as usual..lets hope these clues lead to further investigations and a cure..
Thank you
Sara x
Thanks, Sara. What kind of doc is your sister?
Interesting. I have asthma, which is autoimmune, and endometriosis, which MAY be. I love the autoimmune illness come value packs. More bang for your genetic buck.
Very funny, Amy. 😛
Genetic arguments for disease always drive me nuts when they’re done like this. I’ll have to pull the article, but with such large sample sizes you have tremendous statistical power to find something/anything.
Interesting news on the Syk inhibitor. I wonder what else this drug hits though. Kinase inhibitors are usually very promiscuous and if you hit one you’re likely to hit a bunch of them. Not to rain on a parade, but celluar pathways are tricky and can find their ways around road blocks leading to drug resistance overtime.
I’ve ran across a number of other experimental drugs lately that have RA activity. I’m still following up on them. I’ll drop you a line when I know more.
Yes, do keep an eye on these and let us know what you like. That will be great. There’s a few in that pipeline right now I hear.
Ahhh. I see you figured out where I work. I told you it wouldn’t be hard. Let’s keep it our little secret. Ok?
We have one molecule that I know of that is fairly far along for an RA indication. I don’t know that much about it though. Even if I did know something I’d dare not share anything unless it is published in the public domain.
Boy those kids sure look happy. Great smiles. Nice to see.
I keep up hope for something. Some times just seeing things like kids having fun is enough to give me some relief. Thank you for what you do. Hang in there.
Phil
Thanks, Phil. Just remembering that day made me so happy this morning. Glad someone else “got it”!!
Annual gingerbread house shoot – Brilliant!!
My dad has had type 1 diabetes for 32 years. I have monitored my blood sugar carefully for years, only to be hit with RA instead.
btw, is gingerbread house season just for 1 day on New Years Day?
Bwhahaha. Yes, I hate to waste the hard as a rock gingerbread house. So, I came up with a good use for it. Doesn’t it look fun?
I’m really struggling with yet another’s secondary condition, neutropenia. The toxcilzumab infusions are responsible and they have been the only treatment that keeps me out of a wheelchair though I’m still flaring to varying degrees. So, when the neutrophils drop to low the medics take me off methoject and the infusions which is frightening as hell.
I was also thinking that sjjgrens is underestimated, when I have a real bad bout my mouth is split open, tongue and cheeks and have had many fillings drop out as you have said Kelly elsewhere. I can often only eat akaline food as it’s so v painful. I’m waiting for my wrists to be replaced now, but as my thumbs have been more painful than my wrists I wonder if it will help. I’m a walking catalogue of symptoms and pain and no one in my life wants to hear about it. Rhuematolgy have given up, the proff said I should accept they have got me as well as they can and I’m now at the top of the treatment tree. I have had to return to steroids much as I hate them and after it took me two years to get off them. And am taking the higher doses of opiates though I won’t return to oramorph as it made me feel so spaced out all the time. After 12 years I can’t even remember all the co morbidities that I have been told I have, the casual oh yes that’s vasculitis, puts me into so much shock (yes I still do get shocked surprisingly) I dread mentioning another new symptom. Now I’m 63 I’m beginning to fear the future more than I have.
When o read your blog on trailing steroids I thought it sounded like you didn’t use them to help dampen extreme flares, I met a woman in Rhuematolgy who has adverse reactions to most of the RD drugs so has to live with it as it comes, she was wheelchair bound needless to say. I have been told I’m in to top 2% of aggression in the U.K. Great! And told its galloping – whatever that brings.
Apologies – I haven’t stayed true to the vein which you were discussing but it sort of poured out.
I meant to add how frightening it is to read what can happen with neutropenia, sepsis another form of immune attack. The body can get totally miswired and send haywire messages that can kill.