Why would musculoskeletal ultrasound matter to Rheumatoid Disease patients?
In Rheumatoid Arthritis Swelling, Take Two (2011), I told you about a study by Dr. A.K. Brown that showed 96% of people judged by rheumatologists to be in “clinical remission” actually showed disease activity when examined with expert ultrasound or MRI. That study corroborated the comments of thousands of persons with Rheumatoid Disease (PRD) on this site: that they experience signs of disease activity even if external swelling is inconspicuous, such as the 460 of them here and here.
3 sample patient comments:
The new news on musculoskeletal ultrasound (MSUS)
Read the words of Dr. Stephen Kelly at EULAR last month in Madrid: “‘You can see raging inflammation in joints that are not swollen or tender,’ he said in an interview. The discrepancy between clinical symptoms and the ultrasound appearance can be ‘surprising,’ said Dr. Kelly, a rheumatologist at Mile End Hospital in Barts Health NHS Trust in London” (reported in Rheumatology News  (emphasis added). It’s not so surprising to us. But RAW was pleased to see that the evidence is being pursued and discussed. Anyone reading a sample of those comments can see how sorely that evidence is needed (pun for fun). And there are indications that some experts are recognizing this:
1. Last year in D.C. at the ACR’s annual meeting, instruction was offered in ultrasound.
2. The presentation on ultrasound by Dr. Kelly was only one of those at EULAR this year.
3. Earlier in 2013, EULAR passed a list of 10 recommendations for imaging in Rheumatoid patients.
4. The importance of MSUS is being investigated in young Rheumatoid patients (JRA / JA).
5. A recent systematic literature review on MSUS concluded: “PDUS (power Doppler ultrasound) has additional value to clinical examination both in improving early diagnosis of RA and establishing true RA remission.”
Why isn’t ultrasound available for Rheumatoid Disease patients?
“Ultrasound” is used in several medical specialties. I’ve had one one of my thyroid, and one of Roo before he was born; and my bff had an ultrasound of her breasts a few years back. But ultrasound of the musculoskeletal system is hard to come by in the U.S.
1. Machines are an expense that practices do not have resources for right now.
2. Doctors have more than enough to do in the short appointments they have with PRD. Most of them are unaware of the impact MSUS could have on their patients.
3. But the biggest reason is lack of training in MSUS, so we’ll look at that next time. It’s tough to find a rheumatologist office that owns an ultrasound machine; and if you do, it’s likely she/he has only been taught to use it for guiding injections.
I can’t say it often enough: there is still so much to learn about RD. The duty of all in medicine is first to do no harm, and this is difficult with a disease that’s been such a mystery. But the situation should not continue the way it is – many patients are harmed by late diagnosis or refusal to treat because a doctor does not recognize that disease activity exists when they don’t detect what is (in their opinion) conspicuous swelling.
Don’t miss part 2 in this series: Musculoskeletal Ultrasound in Rheumatoid Arthritis: Training Is Essential
- All posts on MSUS
- 14-3-3eta Marker in Rheumatoid Arthritis Patients with Low CRP
- Accurately Measuring Rheumatoid Disease Activity
- Does It Matter Whether Rheumatoid Arthritis Affects DIP Joints?
- The very popular first Frying Pan post: Rheumatoid Arthritis Swelling, Take Two
The picture: the blurry image is a foot ultrasound (public domain). You can view much clearer ones at Ultrasoundpaedia where ultrasound methods are outlined. I’d love to show this site to the docs who’ve told me there’s no such animal as MSUS.
 Brown AK, Quinn MA, Karim Z, Conaghan PG, Peterfy CG, Hensor E, Wakefield RJ, O’Connor PJ, Emery P. Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug–induced clinical remission: Evidence from an imaging study may explain structural progression. Arthritis Rheum. 2006 Dec [cited 2013 Aug 3];54(12):3761–3773. Available from: http://onlinelibrary.wiley.com/store/10.1002/art.22190/asset/22190_ftp.pdf?v=1&t=hjwu6cbq&s=a90ec1f341093085e7bb0dcffdf8e1d5cf8179c7
 Zoler ML. Ultrasound speeds new RA diagnoses. Rheumatology News [website]. 2013 Jul 11 [cited 2013 Aug 3]. Available from: http://www.rheumatologynews.com/specialty-focus/rheumatoid-arthritis/single-article-page/ultrasound-speeds-new-ra-diagnoses/
 Colebatch AN, Edwards CJ, Østergaard M, van der Heijde D, Balint PV, D’Agostino MA, Forslind K, Grassi W, Haavardsholm EA, Haugeberg G, et al. EULAR recommendations for the use of imaging of the joints in the clinical management of rheumatoid arthritis. Ann Rheum Dis. 2013 Mar 21 [cited 2013 Aug 3]; Recommendation. Available from: http://ard.bmj.com/content/early/2013/03/20/annrheumdis-2012-203158.full
 Ten Cate DF, Luime JJ, Swen N, Gerards AH, De Jager MH, Basoski NM, Hazes JMW, Haagsma CJ, Jacobs JWG. Role of ultrasonography in diagnosing early rheumatoid arthritis and remission of rheumatoid arthritis – a systematic review of the literature. Arthritis Res Ther 2013 [cited 2013 Aug 6];15:R4. Available from: http://arthritis-research.com/content/pdf/ar4132.pdf