Prevent RA Just Like Cancer

Could methotrexate prevent RA? Several studies presented at the American College of Rheumatology’s (ACR) Annual Scientific Meeting in Chicago last fall are investigating how to prevent RA. One poster in particular, from the Netherlands’ group, presented startling results as they re-analyzed data from the PROMPT trial. They concluded that a one-year course of methotrexate could prevent RA or delay its development.1 I...Continue reading      3 Comments » Read more

Remaining Pain with Rheumatoid Arthritis Treatment

A common problem: remaining pain with Rheumatoid Arthritis Remaining pain with Rheumatoid Arthritis (RA) has been a topic on RAW since 2009. We've discussed how people manage the common “leftover” symptoms such pain, fatigue, and stiffness while being treated for rheumatoid disease. Leftover or remaining pain is the subject of an interesting abstract reported at the recent...Continue reading      30 Comments » Read more

Efficacy of Xeljanz, Biologics, & DMARDs in Rheumatoid Disease

Why should I feel like I failed? I’m not alone We probably agree it’s unfair to say, “patients fail treatments” instead of the reverse, but there is still disappointment. I was optimistic that my Rheumatoid disease would respond to Xeljanz, the new oral DMARD (disease modifying anti-rheumatic drug) from Pfizer. Unfortunately, my joint stiffness and inflammation,...Continue reading      44 Comments » Read more

New England Compounding Center and Beyond: Medications Warnings and Dangers

When there are warnings of dangers related to medication, there is greater risk to chronic disease patients for two reasons: First, we may be more likely to use the drugs in question. And second, we are more vulnerable because we have a systemic illness. Several news reports over the past few weeks are especially relevant...Continue reading      8 Comments » Read more

The End of the Methotrexate Shortage, Thanks to Pfizer?

Pfizer addresses U.S. methotrexate shortage that hurts RA patients Earlier this year the FDA approved an abbreviated new drug application, securing Pfizer’s right to sell injectable methotrexate in the U.S. Recently, Pfizer says they began shipping to customers. This move by Pfizer addresses an urgent shortage of methotrexate in the U.S. that has affected many Rheumatoid...Continue reading      21 Comments » Read more

RA News: Pfizer Pill Beats Methotrexate, Alcohol Reduces RA Risk, Periodontal Disease High

Pfizer oral JAK “superior” to methotrexate Pfizer released a statement about their two year study, ORAL Start, which puts their new oral JAK treatment for Rheumatoid Arthritis directly up against methotrexate.  The oral medication, currently called tofacitinib, is taken twice daily in either 5 or 10 mg doses. “Tofacitinib was found to be superior to MTX...Continue reading      9 Comments » Read more

Confusion & Blame Surround Methotrexate Shortages & Recalls

U.S. caught off guard by methotrexate shortage Shortages of injectable methotrexate began in 2010 and some sources say may continue through 2014. Many have been surprised that shortages of such inexpensive generic drugs could take Americans by surprise and continue for such an indefinite period. Finger-pointing at the FDA and drug companies is probably the one...Continue reading      41 Comments » Read more

Laura’s CVS Commercial with Kelly’s CVS and the “a” Word

Once upon a time, a family switched insurance companies. Mother went to Target to pickup groceries methotrexate with a $10 coupon. When she went to the counter to pay, the insurance had “denied” coverage for the medicine. In the age of cell phones, mother figured she could cure this problem in a moment right there...Continue reading      40 Comments » Read more

Failed Experiment: Methotrexate & Over the Counter Folic Acid

When I met my first rheumatologist, I left with a handful of prescriptions. One for folic acid. Really? Did I need a prescription for a vitamin? Doc said “to make sure it's enough, yes, it’s a lot more than a daily allowance.” I already knew why over the counter supplements (OTC) are not considered as reliably dosed...Continue reading      47 Comments » Read more

A Methotrexate Alternative for Rheumatoid Arthritis?

This molecule has “the potential to further improve the most successful principle of folate inhibition in the treatment” of Rheumatoid Arthritis. Folate antagonism has been the foundation of treatment for Rheumatoid Arthritis for almost two decades. Methotrexate is used to inhibit the proliferation of inflammatory cells, probably at least in part by folate antagonism. There are...Continue reading      30 Comments » Read more

Rheumatoid Arthritis Rheumors: 2 Mysteries Solved

I thought it was brilliant the other day when a commenter called RA “the ghost disease.” It’s true that many RA myths persist and that researchers don’t yet know exactly how Rheumatoid Arthritis works. Which joints can be affected? Is there a nutritional cure that we are overlooking?   Confusion about RA is perpetuated in plenty...Continue reading      32 Comments » Read more

Perception, Reputation, & Information: How Do We Decide about Dangerous Drugs?

Widespread mis-information on methotrexate In an article in The Rheumatologist, Dr. Bruce Cronstein writes about his frustration with misinformation online about methotrexate. He wonders aloud whether there is some intentional campaign against it. I guess many websites paint an ominous picture of the sunny yellow liquid – or pills – we love to hate. There are...Continue reading      60 Comments » Read more

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